Publication

• Shibuya H.
  Telomeres, the nuclear lamina, and membrane remodeling: Orchestrating meiotic chromosome movements.
  Journal of Cell Biology 224(5):e202412135 (2025)
• Stojanovic N, Hernández RO, Ramírez NT, Martínez OME, Hernández AH, Shibuya H.
  CCDC28A deficiency causes head-tail coupling defects and immotility in murine spermatozoa.
  Scientific Reports 14(1):26808 (2024)
• Gurusaran M, Zhang J, Zhang K, Shibuya H, Davies OR.
  MEILB2-BRME1 forms a V-shaped DNA clamp upon BRCA2-binding in meiotic recombination.
  Nature Communications 15(1):6552 (2024)
• Padmanaban S*, Lambacher N*J, Tesmer VM, Zhang J, Shibuya H†, Nandakumar J†.
  Caenorhabditis elegans telomere-binding proteins TEBP-1 and TEBP-2 adapt the Myb module to dimerize and bind telomeric DNA.
  Proc Natl Acad Sci U S A. 121(16):e2316651121 (2024) *co-first authors, † co-corresponding authors
• Zhang J, Ruiz M, Bergh PO, Henricsson M, Stojanović N, Devkota R, Henn M, Bohlooly-Y M, Hernández-Hernández A, Alsheimer M, Borén J, Pilon M, Shibuya H.
  Regulation of meiotic telomere dynamics through membrane fluidity promoted by AdipoR2-ELOVL2.
  Nature Communications 15(1):2315 (2024)
• Liberman N, Rothi MH, Gerashchenko MV, Zorbas C, Boulias K, MacWhinnie FG, Ying AK, Flood Taylor A, Al Haddad J, Shibuya H, Roach L, Dong A, Dellacona S, Lafontaine DLJ, Gladyshev VN, Greer EL.
  18S rRNA methyltransferases DIMT1 and BUD23 drive intergenerational hormesis.
  Molecular Cell S1097-2765(23)00650-0. (2023)
• He S, Gillies JP, Zang JL, Córdoba-Beldad CM, Yamamoto I, Fujiwara Y, Grantham J, DeSantis ME, Shibuya H.
  Distinct dynein complexes defined by DYNLRB1 and DYNLRB2 regulate mitotic and male meiotic spindle bipolarity.
  Nature Communications 14(1):1715 (2023)
• Lu Y, Shimada K, Tang S, Zhang J, Ogawa Y, Noda T, Shibuya H, Ikawa M.
  1700029I15Rik orchestrates the biosynthesis of acrosomal membrane proteins required for sperm-egg interaction.
  Proc Natl Acad Sci U S A. 120(8):e2207263120 (2023)
• Agrawal R, Gillies JP, Zang JL, Zhang J, Garrott SR, Shibuya H†, Nandakumar J†, DeSantis ME†.
  The KASH5 protein involved in meiotic chromosomal movements is a novel dynein activating adaptor.
  eLife 11:e78201 (2022) † co-corresponding authors
• Zhang K, Tarczykowska A, Gupta DK, Pendlebury DF, Zuckerman C, Nandakumar J, Shibuya H.
  The TERB1 MYB domain suppresses telomere erosion in meiotic prophase I.
  Cell Reports 38(4):110289 (2022)
• Zhang J, Nandakumar J, Shibuya H.
  BRCA2 in mammalian meiosis.
  Trends in Cell Biology 32(4):281-284 (2022)
• Pendlebury DF*, Zhang J*, Agrawal R, Shibuya H †, Nandakumar J †.
  Structure of a meiosis-specific complex central to BRCA2 localization at recombination sites.
  Nature Structural and Molecular Biology 28(8):671-680 (2021) *co-first authors, † co-corresponding authors
• Yamamoto I, Zhang K, Zhang J, Vorontsov E, Shibuya H.
  Telomeric double-strand DNA-binding proteins DTN-1 and DTN-2 ensure germline immortality in Caenorhabditis elegans.
  eLife 10:e64104 (2021)
• Fujiwara Y, Horisawa-Takada Y, Inoue E, Tani E, Shibuya H, Fujimura S, Kariyazono R, Sakata T, Ohta K, Araki K, Okada Y, Ishiguro K.
  Meiotic cohesins mediate initial loading of HORMAD1 to the chromosomes and coordinate SC formation during meiotic prophase.
  Plos Genetics 16(9):e1009048 (2020)
• Zhang J*, Gurusaran M*, Fujiwara Y*, Zhang K, Echbarthi M, Vorontsov E, Guo R, Pendlebury D, Alam I, Livera G, Emmanuelle M, Wang P, Nandakumar J, Davies O, Shibuya H.
  The BRCA2-MEILB2-BRME1 complex governs meiotic recombination and impairs the mitotic BRCA2-RAD51 function in cancer cells.
  Nature Communications 11(1):2055 (2020) *co-first authors
• Wang SY*, Mao H*, Shibuya H*, Uzawa S, O’Brown ZK, Wesenberg S, Shin N, Saito TT, Gao J, Meyer BJ, Colaiácovo MP, Greer EL.
  The demethylase NMAD-1 regulates DNA replication and repair in the Caenorhabditis elegans germline.
  Plos Genetics 15(7):e1008252 (2019) *co-first authors
• O’Brown ZK, Boulias K, Wang J, Wang SY, O’Brown NM, Hao Z, Shibuya H, Fady PE, Shi Y, He C, Megason SG, Liu T, Greer EL.
  Sources of artifact in measurements of 6mA and 4mC abundance in eukaryotic genomic DNA.
  BMC Genomics 20(1):445 (2019)
• Zhang J *, Fujiwara Y *, Yamamoto S, Shibuya H.
  A meiosis-specific BRCA2 binding protein recruits recombinases to DNA double-strand breaks to ensure homologous recombination.
  Nature Communications 10(1):722 (2019) *co-first authors
• Shibuya H †, Watanabe Y †.
  Live-cell microscopy of meiosis in spermatocytes.
  Methods in cell biology 145:269-277 (2018) † co-corresponding authors
• Zhang J, Tu Z, Watanabe Y, Shibuya H.
  Distinct TERB1 domains regulate different protein interactions for meiotic telomere movement.
  Cell Reports 21(7):1715-1726 (2017)
• Pendlebury D, Fujiwara Y, Tesmer V, Smith E, Shibuya H, Watanabe Y, Nandakumar J.
  Dissecting the telomere-inner nuclear membrane interface formed in meiosis.
  Nature Structural and Molecular Biology 24(12):1064-1072 (2017)
• Stanzione M, Baumann M, Papanikos F, Dereli I, Lange J, Ramlal A, Tränkner D, Shibuya H, de Massy B, Watanabe Y, Jasin M, Keeney S, Toth A.
  Meiotic DNA break formation requires the unsynapsed chromosome axis-binding protein IHO1 (CCDC36) in mice.
  Nature Cell Biology 18(11):1208-1220 (2016)
• Mikolcevic P, Isoda M, Shibuya H, Barrantes I, Igea A, Suja J, Shackleton S, Watanabe Y, Nebreda A.
  Essential role of the Cdk2 activator RingoA in meiotic telomere tethering to the nuclear envelope.
  Nature Communications 7:11084 (2016)
• Shibuya H, Hernández-Hernández A, Morimoto A, Lumi Negishi, Höög C, Watanabe Y.
  MAJIN links telomeric DNA to the nuclear membrane by exchanging telomere cap.
  Cell 163(5):1252-1266 (2015)
• Shibuya H, Morimoto A, Watanabe Y.
  The Dissection of Meiotic Chromosome Movement in Mice Using an In Vivo Electroporation Technique.
  Plos Genetics 10(12):e1004821 (2014)
• Shibuya H, Watanabe Y.
  The meiosis-specific modification of mammalian telomeres.
  Cell Cycle 13(13):2024-8 (2014) review
• Daniel K, Tränkner D, Wojtasz L, Shibuya H, Watanabe Y, Alsheimer, Toth A.
  Mouse CCDC79 (TERB1) is a meiosis-specific telomere associated protein.
  BMC Cell Biology 15:17 (2014)
• Ishiguro KI, Kim J, Shibuya H, Hernández-Hernández A, Suzuki A, Fukagawa T, Shioi G, Kiyonari H, Li XC, Schimenti J, Höög C, Watanabe Y.
  Meiosis-specific cohesin mediates homolog recognition in mouse spermatocytes.
  Genes and Development 28(6):594-607 (2014)
• Shibuya H, Ishiguro K, Watanabe Y.
  The TRF1-binding protein TERB1 promotes chromosome movement and telomere rigidity in meiosis.
  Nature Cell Biology 16(2):145-56 (2014)
• Morimoto A*, Shibuya H*, Zhu X, Kim J, Ishiguro K, Han M, Watanabe Y.
  A conserved KASH domain protein associates with telomeres, SUN1, and dynactin during mammalian meiosis.
  Journal of Cell Biology 198(2):165-72 (2012) *co-first authors